6nep: Difference between revisions
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==Structure of human PACRG-MEIG1 complex== | |||
<StructureSection load='6nep' size='340' side='right'caption='[[6nep]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6nep]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NEP FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHI:IODO-PHENYLALANINE'>PHI</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6ndu|6ndu]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nep OCA], [http://pdbe.org/6nep PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nep RCSB], [http://www.ebi.ac.uk/pdbsum/6nep PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nep ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PACRG_HUMAN PACRG_HUMAN]] Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.<ref>PMID:14532270</ref> [[http://www.uniprot.org/uniprot/MEIG1_HUMAN MEIG1_HUMAN]] Essential for spermiogenesis. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Croteau, N]] | |||
[[Category: Khan, N]] | |||
[[Category: Pelletier, D]] | |||
[[Category: Trempe, J F]] | |||
[[Category: Veyron, S]] | [[Category: Veyron, S]] | ||
[[Category: | [[Category: Axoneme]] | ||
[[Category: | [[Category: Flagella]] | ||
[[Category: | [[Category: Microtubule]] | ||
[[Category: | [[Category: Primary cilia]] | ||
[[Category: Structural protein]] | |||
Revision as of 06:54, 23 October 2019
Structure of human PACRG-MEIG1 complex
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