CD4: Difference between revisions

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HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>
HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>
*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>
*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>
==3D structures of CD4==
[[CD4 3D structures]]


</StructureSection>
</StructureSection>
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*CD4 domains
*CD4 domains


**[[1cid]] – rCD4 D3 and D4 domains - rat<BR />
**[[3cd4]], [[1cdh]], [[1cdi]], [[1cdj]] – hCD4 D1-D2 domains - human<BR />
**[[3cd4]], [[1cdh]], [[1cdi]], [[1cdj]] – hCD4 D1 and D2 domains - human<BR />
**[[1cdu]], [[1cdy]] – hCD4 D1-D2 domains (mutant)<BR />
**[[1cdu]], [[1cdy]] – hCD4 D1 and D2 domains (mutant)<BR />
**[[1wio]], [[1wip]], [[1wiq]] – hCD4 D1-D4 domains <BR />
**[[1wio]], [[1wip]], [[1wiq]] – hCD4 D1, D2, D3 and D4 domains <BR />
**[[2klu]] – hCD4 transmembrane and tail domains - NMR<BR />
**[[2klu]] – hCD4 transmembrane and tail domains - NMR<BR />
**[[1cid]] – rCD4 D3-D4 domains - rat<BR />


*CD4 binary complex
*CD4 binary complex


**[[3b71]] – hCD4 tail + focal adhesion kinase 1<BR />
**[[3o2d]], [[4q9i]] – hCD4 D1-D2 domains + antibody <BR />
**[[5cay]] – hCD4 D1-D2 domains + gp120 <BR />
**[[1q68]] – hCD4 tail + Lck peptide - NMR<BR />
**[[1q68]] – hCD4 tail + Lck peptide - NMR<BR />
**[[3b71]] – hCD4 tail + focal adhesion kinase 1<BR />
**[[3o2d]], [[4q9i]] – hCD4 D1 and D2 domains + antibody <BR />
**[[5cay]] – hCD4 D1 and D2 domains + gp120 <BR />


*CD4 higher complexes
*CD4 higher complexes


**[[1gc1]], [[1g9m]], [[1g9n]], [[1rzj]], [[1rzk]], [[2b4c]], [[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[3jwd]], [[3jwo]], [[4jm2]], [[4rqs]], [[4r2g]], [[4p9h]], [[4h8w]], [[5a8h]], [[5a7x]] – hCD4 D1 and D2 domains + antibody + gp120<BR />
**[[1gc1]], [[1g9m]], [[1g9n]], [[1rzj]], [[1rzk]], [[2b4c]], [[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[3jwd]], [[3jwo]], [[4jm2]], [[4rqs]], [[4r2g]], [[4p9h]], [[4h8w]], [[5a8h]], [[5a7x]] – hCD4 D1-D2 domains + antibody + gp120<BR />
**[[3j70]], [[5u1f]] – hCD4 D1 and D2 domains + antibody + gp120 + gp41<BR />
**[[3j70]], [[5u1f]] – hCD4 D1-D2 domains + antibody + gp120 + gp41<BR />
**[[5thr]] – hCD4 D1 and D2 domains + antibody + gp120 + gp41 + 8ANC195<BR />
**[[5thr]] – hCD4 D1-D2 domains + antibody + gp120 + gp41 + 8ANC195<BR />
**[[2qad]], [[3lqa]] – hCD4 D1 and D2 domains + antibody + gp160<BR />
**[[2qad]], [[3lqa]], [[6edu]], [[6cm3]], [[5vn3]] – hCD4 D1-D2 domains + antibody + gp160<BR />
**[[1jl4]] – hCD4 D1 and D2 domains + class II MHC + ovotransferin peptide<BR />
**[[1jl4]] – hCD4 D1-D2 domains + class II MHC + ovotransferin peptide<BR />
**[[3s4s]] – hCD4 D1 and D2 domains + class II MHC + haemaglutinin peptide<BR />
**[[3s4s]] – hCD4 D1-D2 domains + class II MHC + haemaglutinin peptide<BR />
**[[3s5l]] – hCD4 D1 and D2 domains + class II MHC + HA peptide<BR />
**[[3s5l]] – hCD4 D1-D2 domains + class II MHC + HA peptide<BR />
**[[3t0e]] – hCD4 D1 and D2 domains + class II MHC + TCR<BR />
**[[3t0e]] – hCD4 D1-D2 domains + class II MHC + TCR<BR />
**[[6meo]], [[6met]] – hCD4 D1-D3 domains + CCR5 + gp120<BR />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]
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