DnaA: Difference between revisions

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'''DnaA''' activates initiation of DNA replication in prokaryotes. DnaA promotes the unwinding of the DNA helix. The cellular concentration of DnaA determines the initiation of DNA replication. Active DnaA is bound to ATP. DnaA binds to DNA at a specific 9 base pair DnaA box in oriC (origin of replication sequence). <ref>PMID:17435790</ref>

'''DnaA''' or '''chromosomal replication initiator protein DnaA''' activates initiation of DNA replication in prokaryotes. DnaA promotes the unwinding of the DNA helix. The cellular concentration of DnaA determines the initiation of DNA replication. Active DnaA is bound to ATP. DnaA binds to DNA at a specific 9 base pair DnaA box in oriC (origin of replication sequence). <ref>PMID:17435790</ref>

<scene name='50/509255/Cv/2'>Protein-DNA interface</scene> ([[1j1v]]).<ref>PMID:12682358</ref>

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[[2wp0]] - DnaA N terminal + HOBA – ''Helicobacter pylori''

[[3pvp]], [[3pvv]] - DnaA DNA binding domain + DNA – ''Mycobacterium tuberculosis''

[[4tps]] - ~~DnaA~~ domain I + SirA – ''Bacillus subtilis''

[[4tps]] - BsDnaA domain I 1-82 + SirA – ''Bacillus subtilis''

[[8bv3]] - BsDnaA domain III 106-346

[[8btg]] - BsDnaA + DNA – Cryo EM

== References ==

[[Category:Topic Page]]

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 <StructureSection load='' size='350' side='right' scene='50/509255/Cv/1' caption='E. coli DnaA complex with DNA ([[1j1v]])'>
-'''DnaA''' activates initiation of DNA replication in prokaryotes.  DnaA promotes the unwinding of the DNA helix.  The cellular concentration of DnaA determines the initiation of DNA replication.  Active DnaA is bound to ATP.  DnaA binds to DNA at a specific 9 base pair DnaA box in oriC (origin of replication sequence). <ref>PMID:17435790</ref>
+'''DnaA''' or '''chromosomal replication initiator protein DnaA''' activates initiation of DNA replication in prokaryotes.  DnaA promotes the unwinding of the DNA helix.  The cellular concentration of DnaA determines the initiation of DNA replication.  Active DnaA is bound to ATP.  DnaA binds to DNA at a specific 9 base pair DnaA box in oriC (origin of replication sequence). <ref>PMID:17435790</ref>
 <scene name='50/509255/Cv/2'>Protein-DNA interface</scene> ([[1j1v]]).<ref>PMID:12682358</ref>
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 [[2wp0]] - DnaA N terminal + HOBA – ''Helicobacter pylori''<br />
 [[3pvp]], [[3pvv]] - DnaA DNA binding domain + DNA – ''Mycobacterium tuberculosis''<br />
-[[4tps]] - DnaA domain I + SirA – ''Bacillus subtilis''<br />
+[[4tps]] - BsDnaA domain I 1-82 + SirA – ''Bacillus subtilis''<br />
+[[8bv3]] - BsDnaA domain III 106-346<br />
+[[8btg]] - BsDnaA + DNA – Cryo EM<br />
 == References ==
 <references/>
 [[Category:Topic Page]]