1q3a: Difference between revisions

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<StructureSection load='1q3a' size='340' side='right'caption='[[1q3a]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='1q3a' size='340' side='right'caption='[[1q3a]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1q3a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q3A FirstGlance]. <br>
<table><tr><td colspan='2'>[[1q3a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q3A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g49|1g49]], [[1bqo|1bqo]], [[1d5j|1d5j]], [[1d8f|1d8f]], [[1uea|1uea]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g49|1g49]], [[1bqo|1bqo]], [[1d5j|1d5j]], [[1d8f|1d8f]], [[1uea|1uea]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MMP10 OR STMY2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MMP10 OR STMY2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stromelysin_2 Stromelysin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.22 3.4.24.22] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Stromelysin_2 Stromelysin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.22 3.4.24.22] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3a OCA], [http://pdbe.org/1q3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q3a RCSB], [http://www.ebi.ac.uk/pdbsum/1q3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q3a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3a OCA], [https://pdbe.org/1q3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q3a RCSB], [https://www.ebi.ac.uk/pdbsum/1q3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q3a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MMP10_HUMAN MMP10_HUMAN]] Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.  
[[https://www.uniprot.org/uniprot/MMP10_HUMAN MMP10_HUMAN]] Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Matrix metalloproteinase|Matrix metalloproteinase]]
*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
== References ==
== References ==
<references/>
<references/>

Revision as of 06:02, 28 April 2021

Crystal structure of the catalytic domain of human matrix metalloproteinase 10

1q3a, resolution 2.10Å

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