Tryptophan synthase: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
The <scene name='52/525189/Cv/6'>active site</scene> of TrpS subunit α contains the catalytic residues Glu and Asp<ref>PMID:16120446</ref>. Water molecules are shown as red spheres.
The <scene name='52/525189/Cv/6'>active site</scene> of TrpS subunit α contains the catalytic residues Glu and Asp<ref>PMID:16120446</ref>. Water molecules are shown as red spheres.
==3D structures of tryptophan synthase==
[[Tryptophan synthase 3D structures]]


</StructureSection>
</StructureSection>
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*'''Tryptophan synthase α subunit'''
*'''Tryptophan synthase α subunit'''


**[[1rd5]] - TrpS α subunit – corn<br />
**[[3vnd]] - TrpS α subunit – ''Shewanella frigidimarina''<br />
**[[3vnd]] - TrpS α subunit – ''Shewanella frigidimarina''<br />
**[[3tha]] - TrpS α subunit – ''Campylobacter jejuni''<br />
**[[3tha]] - TrpS α subunit – ''Campylobacter jejuni''<br />
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**[[1geq]] - PfTrpS α subunit - ''Pyrococcus furiosus''<br />
**[[1geq]] - PfTrpS α subunit - ''Pyrococcus furiosus''<br />
**[[2dzp]], [[2dzs]], [[2dzt]], [[2dzu]], [[2dzv]], [[2dzw]], [[2dzx]], [[2e09]] - PfTrpS α subunit (mutant)<br />
**[[2dzp]], [[2dzs]], [[2dzt]], [[2dzu]], [[2dzv]], [[2dzw]], [[2dzx]], [[2e09]] - PfTrpS α subunit (mutant)<br />
**[[1rd5]] - TrpS α subunit – corn<br />
**[[1ujp]] - TtTrpS α subunit <br />
**[[1ujp]] - TtTrpS α subunit <br />
**[[1v7y]], [[1wq5]], [[1xc4]] - EcTrpS α subunit <br />
**[[1v7y]], [[1wq5]], [[1xc4]] - EcTrpS α subunit <br />
**[[1xcf]] - EcTrpS α subunit (mutant)<br />
**[[1xcf]] - EcTrpS α subunit (mutant)<br />
**[[2ekc]] - TrpS α subunit – ''Aquifex aeolicus''<br />
**[[2ekc]] - TrpS α subunit – ''Aquifex aeolicus''<br />
**[[5kmy]], [[5k9x]] - TrpS α subunit – ''Legionella pneumophila''<br />
**[[5kmy]], [[5k9x]], [[6oky]] - TrpS α subunit – ''Legionella pneumophila''<br />
**[[5n2p]] - SsTrpS α subunit – ''Sulfolobus solfataricus''<br />


*Tryptophan synthase α binary complex
*Tryptophan synthase α binary complex
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**[[1v8z]] - PfTrpS β1 subunit <br />
**[[1v8z]] - PfTrpS β1 subunit <br />
**[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br />
**[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br />
**[[4qys]] - SsTrpS β2 subunit – ''Sulfolobus solfataricus''<br />
**[[4qys]], [[6hte]] - SsTrpS β2 subunit<br />


*Tryptophan synthase β complex
*Tryptophan synthase β complex
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**[[1wdw]] - PfTrpS α + β subunits <br />
**[[1wdw]] - PfTrpS α + β subunits <br />
**[[6hul]] - SsTrpS α + β subunits <br />


*Tryptophan synthase α+β binary complex
*Tryptophan synthase α+β binary complex
   
   
**[[1ttp]], [[1ttq]], [[1bks]], [[2wsy]], [[1kfk]] - StTrpS α + β + PLP – ''Salmonella typhimurium''<br />
**[[1ttp]], [[1ttq]], [[1bks]], [[2wsy]], [[1kfk]] - StTrpS α + β + PLP – ''Salmonella typhimurium''<br />
**[[1k7x]], [[2j9z]] - StTrpS α + β (mutant) + PLP<br />
**[[3pr2]], [[4hn4]], [[4hpj]], [[4hpx]], [[4ht3]], [[4kkx]] - StTrpS α + β + inhibitor<br />
**[[1kfj]] - StTrpS α + β + pyridoxal-serine-monophsphate<br />
**[[1a5a]], [[1k8x]] - StTrpS α (mutant) + β + PLP<br />
**[[1a5a]], [[1k8x]] - StTrpS α (mutant) + β + PLP<br />
**[[1k7x]], [[2j9z]] - StTrpS α + β (mutant) + PLP<br />
**[[2tys]] - StTrpS α (mutant) + β (mutant) + Trp derivative<br />
**[[1kfe]] - StTrpS α (mutant) + β + pyridoxal-serine-monophsphate<br />
**[[1kfe]] - StTrpS α (mutant) + β + pyridoxal-serine-monophsphate<br />
**[[1kfj]] - StTrpS α + β + pyridoxal-serine-monophsphate<br />
**[[6o1h]], [[6dzo]], [[6duc]], [[6d0v]], [[6c73]] - StTrpS α + β (mutant) + inhibitor<br />
**[[2j9y]] - StTrpS α + β (mutant) + enoic acid derivative<br />
**[[2j9y]] - StTrpS α + β (mutant) + enoic acid derivative<br />
**[[3pr2]], [[4hn4]], [[4hpj]], [[4hpx]], [[4ht3]], [[4kkx]] - StTrpS α + β + inhibitor<br />
**[[2tys]] - StTrpS α (mutant) + β (mutant) + Trp derivative<br />
**[[5kzm]] - TrpS α + β + PLP derivative – ''Francisella tularensis''<br />
**[[5kzm]] - TrpS α + β + PLP derivative – ''Francisella tularensis''<br />
**[[5kin]] - TrpS α + β + PLP derivative – ''Streptococcus pneumoniae''<br />
**[[5kin]] - TrpS α + β + PLP derivative – ''Streptococcus pneumoniae''<br />

Revision as of 09:11, 11 March 2020

Tryptophan synthaseα subunit (yellow, salmon) and β subunit (cyan, green) of the α2β2 tetramer complex with pyridoxal-phosphate, glycerol-3-phosphate and Na+ ion (purple) 1wbj

Drag the structure with the mouse to rotate

3D structures of tryptophan synthase

Updated on 11-March-2020

    • 1ttp, 1ttq, 1bks, 2wsy, 1kfk - StTrpS α + β + PLP – Salmonella typhimurium
    • 1k7x, 2j9z - StTrpS α + β (mutant) + PLP
    • 3pr2, 4hn4, 4hpj, 4hpx, 4ht3, 4kkx - StTrpS α + β + inhibitor
    • 1kfj - StTrpS α + β + pyridoxal-serine-monophsphate
    • 1a5a, 1k8x - StTrpS α (mutant) + β + PLP
    • 1kfe - StTrpS α (mutant) + β + pyridoxal-serine-monophsphate
    • 6o1h, 6dzo, 6duc, 6d0v, 6c73 - StTrpS α + β (mutant) + inhibitor
    • 2j9y - StTrpS α + β (mutant) + enoic acid derivative
    • 2tys - StTrpS α (mutant) + β (mutant) + Trp derivative
    • 5kzm - TrpS α + β + PLP derivative – Francisella tularensis
    • 5kin - TrpS α + β + PLP derivative – Streptococcus pneumoniae
    • 5e0k - PfTrpS α + β + PLP derivative
    • 5ocw, 5tcg, 5tci, 5tcj - MtTrpS α + β + inhibitor
    • 5tcf - MtTrpS α + β + PLP derivative
    • 5tch - MtTrpS α + β (mutant) + PLP derivative
    • 5e0k - PfTrpS α + β + PLP derivative
  • Tryptophan synthase α+β ternary complex with PLP and inhibitor
  • Tryptophan synthase α+β ternary complex with PLP and IGP derivatives
    • 1a5b, 1kfb - StTrpS α (mutant) + β + IGP + PLP
    • 1k8z - StTrpS α + β (mutant) + IGP derivative + PLP
    • 1kfc - StTrpS α (mutant) + β + IGP derivative + PLP
    • 1k3u, 1k7e, 1k7f - StTrpS α + β + IGP derivative + PLP
    • 1qoq, 2rh9, 2rhg - StTrpS α + β + IGP + PLP
    • 1qop - StTrpS α + β + IGP analog + PLP
    • 2trs, 1beu - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + IGP analog
  • Tryptophan synthase α+β ternary complex with PLP and G3P derivatives
    • 1wbj - StTrpS α + β + G3P + PLP
    • 2j9x - StTrpS α + β + G3P + acrylic acid derivative
    • 1k8y - StTrpS α + β (mutant) + G3P derivative + PLP
    • 1tjp - StTrpS α + β + G3P derivative + PLP
    • 2tsy - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + G3P
    • 1ubs - StTrpS α (mutant) + β (mutant) + serine + PLP
  • Tryptophan synthase α+β quaternary complex
    • 1a5s - StTrpS α + β + serine + inhibitor + PLP
    • 5cgq - StTrpS α + β + Trp + inhibitor + PLP
    • 3cep - StTrpS α + β + G3P + indoline + PLP
    • 6uap, 6ub9, 6dwe, 6e9p - MtTrpS α + β + malonate + inhibitor + PLP derivative

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Amer Ali, Joel L. Sussman

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