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Line 26: |
| **[[2rmn]] – hP63 - human - NMR<br /> | | **[[2rmn]] – hP63 - human - NMR<br /> |
| **[[3qym]], [[3qyn]], [[3us0]], [[3us1]], [[3us2]] – hP63 + DNA<br /> | | **[[3qym]], [[3qyn]], [[3us0]], [[3us1]], [[3us2]] – hP63 + DNA<br /> |
| | **[[7z71]], [[7z7e]] – hP63 + darpin<br /> |
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| *p63 tetramerization domain (397-455) | | *p63 tetramerization domain (397-455) |
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Line 32: |
| **[[3zy0]], [[3zy1]], [[4a9z]] – hP63 <br /> | | **[[3zy0]], [[3zy1]], [[4a9z]] – hP63 <br /> |
| **[[2nb1]] – hP63 + p73 tetramerization domain - NMR<br /> | | **[[2nb1]] – hP63 + p73 tetramerization domain - NMR<br /> |
| | **[[7z73]] – hP63 + darpin<br /> |
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| *p63 C terminal domain (501-575) | | *p63 C terminal domain (501-575) |
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Line 42: |
| **[[2y9t]] – hP63 - NMR<br /> | | **[[2y9t]] – hP63 - NMR<br /> |
| **[[2y9u]] – hP63 (mutant)<br /> | | **[[2y9u]] – hP63 (mutant)<br /> |
| | **[[7z72]] – hP63 + darpin<br /> |
| **[[5n2o]] – P63 (mutant) - mouse<br /> | | **[[5n2o]] – P63 (mutant) - mouse<br /> |
| }} | | }} |
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Function
p63 is a tumor protein belonging to the p53 family. It is a multi-isoform protein required for epidermal development[1]. p63 domains structure is similar to that of p53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain. In addition, the p63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains. The SAM domain is involved in protein-protein interactions.
Disease
Mutations in p63 result in cleft lip or palate syndromes, split hand/foot malformation or ectodermal dysplasia[2], [3].
Relevance
One isoform of p63 is involved in skin development and stem/progenitor cell regulation[4]. Another isoform functions in apoptosis[5].
Structural highlights
- ↑ Parsa R, Yang A, McKeon F, Green H. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol. 1999 Dec;113(6):1099-105. PMID:10594758 doi:https://dx.doi.org/10.1046/j.1523-1747.1999.00780.x
- ↑ Leoyklang P, Siriwan P, Shotelersuk V. A mutation of the p63 gene in non-syndromic cleft lip. J Med Genet. 2006 Jun;43(6):e28. PMID:16740912 doi:43/6/e28
- ↑ Tadini G, Santagada F, Brena M, Pezzani L, Nannini P. Ectodermal dysplasias: the p63 tail. G Ital Dermatol Venereol. 2013 Feb;148(1):53-8. PMID:23407076
- ↑ Koster MI, Dai D, Roop DR. Conflicting roles for p63 in skin development and carcinogenesis. Cell Cycle. 2007 Feb 1;6(3):269-73. Epub 2007 Feb 3. PMID:17224652 doi:https://dx.doi.org/10.4161/cc.6.3.3792
- ↑ Petre-Lazar B, Livera G, Moreno SG, Trautmann E, Duquenne C, Hanoux V, Habert R, Coffigny H. The role of p63 in germ cell apoptosis in the developing testis. J Cell Physiol. 2007 Jan;210(1):87-98. PMID:16998800 doi:https://dx.doi.org/10.1002/jcp.20829
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3D Structures of P63
Updated on 21-August-2023
{"openlevels":0}
- p63 DBD (153-384)
- p63 tetramerization domain (397-455)
- p63 C terminal domain (501-575)
- p63 SAM domain (543-622)
- 2y9t – hP63 - NMR
- 2y9u – hP63 (mutant)
- 7z72 – hP63 + darpin
- 5n2o – P63 (mutant) - mouse
References
