6vj5: Difference between revisions
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==== | ==Structure of PE25-PPE41(A124L) in complex with EspG5 chaperone from the type VII (ESX-5) secretion system== | ||
<StructureSection load='6vj5' size='340' side='right'caption='[[6vj5]]' scene=''> | <StructureSection load='6vj5' size='340' side='right'caption='[[6vj5]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[6vj5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_marinum_M Mycobacterium marinum M] and [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VJ5 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vj5 OCA], [https://pdbe.org/6vj5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vj5 RCSB], [https://www.ebi.ac.uk/pdbsum/6vj5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vj5 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vj5 OCA], [https://pdbe.org/6vj5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vj5 RCSB], [https://www.ebi.ac.uk/pdbsum/6vj5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vj5 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PE25_MYCTU PE25_MYCTU] The PE25/PPE41 dimer induces both a strong humoral and cellular immune response. PE25 protein alone induces low response (PubMed:18974870). The dimer induces necrosis, but not apoptosis, in mouse macrophage cells (PubMed:25379378). It also induces activation and maturation of mouse dendritic cells and drives Th2-biased immune responses (PubMed:26318856).<ref>PMID:18974870</ref> <ref>PMID:25379378</ref> <ref>PMID:26318856</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mycobacterium marinum M]] | ||
[[Category: Mycobacterium tuberculosis H37Rv]] | |||
[[Category: Korotkov KV]] | |||
[[Category: Williamson ZA]] | |||
Latest revision as of 08:13, 11 October 2023
Structure of PE25-PPE41(A124L) in complex with EspG5 chaperone from the type VII (ESX-5) secretion system
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