2ew1: Difference between revisions
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<StructureSection load='2ew1' size='340' side='right'caption='[[2ew1]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2ew1' size='340' side='right'caption='[[2ew1]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ew1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ew1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EW1 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ew1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ew1 OCA], [https://pdbe.org/2ew1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ew1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ew1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ew1 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ew1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ew1 OCA], [https://pdbe.org/2ew1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ew1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ew1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ew1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/RAB30_HUMAN RAB30_HUMAN] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bochkarev | [[Category: Bochkarev A]] | ||
[[Category: Edwards | [[Category: Edwards AM]] | ||
[[Category: Ismail | [[Category: Ismail S]] | ||
[[Category: Park | [[Category: Park HW]] | ||
[[Category: Shen Y]] | |||
[[Category: Shen | [[Category: Sundstrom M]] | ||
[[Category: Sundstrom | [[Category: Wang J]] | ||
[[Category: Wang | |||
Latest revision as of 07:40, 23 August 2023
Crystal Structure of Rab30 in complex with a GTP analogue
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