Nonstructural protein

spinqualitylabelsall models Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry 1nhu) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Nonstructural protein (NS) is a protein encoded by a virus which is not part of the viral particle. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro). For homology model and multiple sequence alignment see User:Michael Strong/H1N1/NS User:Michael Strong/H1N1/NS1/MSA User:Michael Strong/H1N1/NS2/MSA Student Project 4 for UMass Chemistry 423 Spring 2015. For NS1 of SARS-CoV-2 see SARS-CoV-2 protein NSP1. For NS3 of SARS-CoV-2 see SARS-CoV-2 enzyme Papain-like. For NS7 or replicase polyprotein 1ab light chain of SARS-CoV-2 see SARS-CoV-2 protein NSP7. For NS8 or replicase polyprotein 1ab heavy chain of SARS-CoV-2 see SARS-CoV-2 protein NSP8. For NS9 of SARS-CoV-2 see SARS-CoV-2 protein NSP9. For NS10 or replicase polyprotein 1ab of SARS-CoV-2 see SARS-CoV-2 protein NSP10. For NS12 of SARS-CoV-2 see also Vitamin B12 may inhibit RNA-dependent-RNA polymerase activity of nsp12 from the SARS-CoV-2 vi. For NS12+NS8+NS7 or RNA-dependent RNA polymerase of SARS-CoV-2 see SARS-CoV-2 enzyme RdRp. SARS-CoV-2 NS12+NS8+NS7+NS13+RNA is called replication-transcription complex. For NS16+NS10 of SARS-CoV-2 see SARS-CoV-2 enzyme 2'-O-MT. Relevance The drug Victrelis (generic name boceprevir) binds to NS3 of the hepatitis C virus and is used for treatment of the disease. See Bailey Dove/Victrelis. Structural highlights Hepatitis virus NS active site shows hydrogen bond interactions and hydrophobic pocket interactions. 3D Structures of Nonstructural protein Nonstructural protein 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel