1by5: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1by5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Ustilago_sphaerogena Ustilago sphaerogena]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BY5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1by5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Ustilago_sphaerogena Ustilago sphaerogena]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BY5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=OES:N-OCTYL-2-HYDROXYETHYL+SULFOXIDE'>OES</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AHO:N-ACETYL-N-HYDROXY-L-ORNITHINE'>AHO</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AHO:N-ACETYL-N-HYDROXY-L-ORNITHINE'>AHO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=OES:N-OCTYL-2-HYDROXYETHYL+SULFOXIDE'>OES</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1by5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1by5 OCA], [https://pdbe.org/1by5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1by5 RCSB], [https://www.ebi.ac.uk/pdbsum/1by5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1by5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1by5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1by5 OCA], [https://pdbe.org/1by5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1by5 RCSB], [https://www.ebi.ac.uk/pdbsum/1by5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1by5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/FHUA_ECOLI FHUA_ECOLI]] This receptor binds the ferrichrome-iron ligand. It interacts with the TonB protein, which is responsible for energy coupling of the ferrichrome-promoted iron transport system. Acts as a receptor for bacteriophage T5 as well as T1, phi80 and colicin M. Binding of T5 triggers the opening of a high conductance ion channel. Can also transport the antibiotic albomycin.<ref>PMID:8617231</ref>
[https://www.uniprot.org/uniprot/FHUA_ECOLI FHUA_ECOLI] This receptor binds the ferrichrome-iron ligand. It interacts with the TonB protein, which is responsible for energy coupling of the ferrichrome-promoted iron transport system. Acts as a receptor for bacteriophage T5 as well as T1, phi80 and colicin M. Binding of T5 triggers the opening of a high conductance ion channel. Can also transport the antibiotic albomycin.<ref>PMID:8617231</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ustilago sphaerogena]]
[[Category: Ustilago sphaerogena]]
[[Category: Koebnik, R]]
[[Category: Koebnik R]]
[[Category: Locher, K P]]
[[Category: Locher KP]]
[[Category: Mitschler, A]]
[[Category: Mitschler A]]
[[Category: Moras, D]]
[[Category: Moras D]]
[[Category: Moulinier, L]]
[[Category: Moulinier L]]
[[Category: Rees, B]]
[[Category: Rees B]]
[[Category: Rosenbusch, J P]]
[[Category: Rosenbusch JP]]
[[Category: Ferrichrome]]
[[Category: Fhua]]
[[Category: Iron transport]]
[[Category: Ligand-gated]]
[[Category: Membrane protein]]
[[Category: Metal binding protein]]

Latest revision as of 07:47, 15 November 2023

FHUA FROM E. COLI, WITH ITS LIGAND FERRICHROME

1by5, resolution 2.60Å

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