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==The X-ray structure of L-threonine dehydrogenase from the common hospital pathogen Clostridium difficile.== | ==The X-ray structure of L-threonine dehydrogenase from the common hospital pathogen Clostridium difficile.== | ||
<StructureSection load='7ol1' size='340' side='right'caption='[[7ol1]]' scene=''> | <StructureSection load='7ol1' size='340' side='right'caption='[[7ol1]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OL1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7ol1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_difficilis"_hall_and_o'toole_1935 "bacillus difficilis" hall and o'toole 1935]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OL1 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ol1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ol1 OCA], [https://pdbe.org/7ol1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ol1 RCSB], [https://www.ebi.ac.uk/pdbsum/7ol1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ol1 ProSAT]</span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cdgr_08060, NCTC13307_02322, SAMEA1402406_00083, SAMEA3375037_00176 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1496 "Bacillus difficilis" Hall and O'Toole 1935])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/L-threonine_3-dehydrogenase L-threonine 3-dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.103 1.1.1.103] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ol1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ol1 OCA], [https://pdbe.org/7ol1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ol1 RCSB], [https://www.ebi.ac.uk/pdbsum/7ol1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ol1 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
In many prokaryotes, the first step of threonine metabolism is catalysed by the enzyme threonine dehydrogenase (TDH), which uses NAD(+) to oxidize its substrate to 2-amino-3-ketobutyrate. The absence of a functional TDH gene in humans suggests that inhibitors of this enzyme may have therapeutic potential against pathogens which are reliant on this enzyme. Here, TDH from Clostridium difficile has been cloned and overexpressed, and the X-ray structure of the apoenzyme form has been determined at 2.6 A resolution. | |||
The X-ray structure of L-threonine dehydrogenase from the common hospital pathogen Clostridium difficile.,Adjogatse E, Bennett J, Guo J, Erskine PT, Wood SP, Wren BW, Cooper JB Acta Crystallogr F Struct Biol Commun. 2021 Aug 1;77(Pt 8):269-274. doi:, 10.1107/S2053230X21007135. Epub 2021 Jul 28. PMID:34341193<ref>PMID:34341193</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7ol1" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bacillus difficilis hall and o'toole 1935]] | |||
[[Category: L-threonine 3-dehydrogenase]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cooper | [[Category: Cooper, J B]] | ||
[[Category: Guo J]] | [[Category: Guo, J]] | ||
[[Category: Apoenzyme]] | |||
[[Category: Dehydrogenase]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 05:56, 6 October 2021
The X-ray structure of L-threonine dehydrogenase from the common hospital pathogen Clostridium difficile.
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