2pq5: Difference between revisions

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<StructureSection load='2pq5' size='340' side='right'caption='[[2pq5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2pq5' size='340' side='right'caption='[[2pq5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2pq5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PQ5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2pq5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PQ5 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gwo|2gwo]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DUSP13, TMDP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pq5 OCA], [https://pdbe.org/2pq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pq5 RCSB], [https://www.ebi.ac.uk/pdbsum/2pq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pq5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pq5 OCA], [https://pdbe.org/2pq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pq5 RCSB], [https://www.ebi.ac.uk/pdbsum/2pq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pq5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DS13B_HUMAN DS13B_HUMAN]] Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.<ref>PMID:21360282</ref>
[https://www.uniprot.org/uniprot/DS13B_HUMAN DS13B_HUMAN] Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.<ref>PMID:21360282</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[MAP kinase phosphatase|MAP kinase phosphatase]]
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Barr, A]]
[[Category: Barr A]]
[[Category: Berridge, G]]
[[Category: Berridge G]]
[[Category: Bunkoczi, G]]
[[Category: Bunkoczi G]]
[[Category: Burgess-Brown, N]]
[[Category: Burgess-Brown N]]
[[Category: Delft, F von]]
[[Category: Edwards A]]
[[Category: Edwards, A]]
[[Category: Knapp S]]
[[Category: Knapp, S]]
[[Category: Niesen F]]
[[Category: Niesen, F]]
[[Category: Pantic N]]
[[Category: Pantic, N]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W]]
[[Category: Salah E]]
[[Category: Structural genomic]]
[[Category: Savitsky P]]
[[Category: Salah, E]]
[[Category: Sundstrom M]]
[[Category: Savitsky, P]]
[[Category: Ugochukwu E]]
[[Category: Sundstrom, M]]
[[Category: Uppenberg J]]
[[Category: Ugochukwu, E]]
[[Category: Weigelt J]]
[[Category: Uppenberg, J]]
[[Category: Von Delft F]]
[[Category: Weigelt, J]]
[[Category: Dual specificity phosphatase]]
[[Category: Dusp13]]
[[Category: Hydrolase]]
[[Category: Protein phosphatase]]
[[Category: Sgc]]
[[Category: Testis and skeletal muscle specific dsp]]

Latest revision as of 11:06, 30 August 2023

Crystal structure of Dual specificity protein phosphatase 13 (DUSP13)

2pq5, resolution 2.30Å

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