2moa: Difference between revisions
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==Solution NMR structure of peptide ImI1 (peak 2)== | ==Solution NMR structure of peptide ImI1 (peak 2)== | ||
<StructureSection load='2moa' size='340' side='right'caption='[[2moa | <StructureSection load='2moa' size='340' side='right'caption='[[2moa]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2moa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MOA FirstGlance]. <br> | <table><tr><td colspan='2'>[[2moa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_imperialis Conus imperialis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MOA FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=81S:(4S)-4,5-DISULFANYL-L-NORVALINE'>81S</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PRD_001232:Alpha-conotoxin+ImI+mutant'>PRD_001232</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2moa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2moa OCA], [https://pdbe.org/2moa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2moa RCSB], [https://www.ebi.ac.uk/pdbsum/2moa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2moa ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2moa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2moa OCA], [https://pdbe.org/2moa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2moa RCSB], [https://www.ebi.ac.uk/pdbsum/2moa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2moa ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CA1_CONIM CA1_CONIM] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian neuronal nAChRs (alpha-3/beta-2 > alpha-7 > alpha-3/beta-4). Has no effect on nAChRs composed of alpha-2/beta-2, alpha-3/beta-2, alpha-4/beta-2, alpha-2/beta-4, alpha-3/beta-4, or alpha-4/beta-4 subunits. Acts voltage-independently. Is highly active against the neuromuscular receptor in frog.<ref>PMID:8206995</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Conus imperialis]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chen | [[Category: Chen S]] | ||
[[Category: Heinis | [[Category: Heinis C]] | ||
Revision as of 09:40, 14 June 2023
Solution NMR structure of peptide ImI1 (peak 2)
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