7x41: Difference between revisions

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'''Unreleased structure'''


The entry 7x41 is ON HOLD  until Paper Publication
==Crystal structure of chlorotoxin, a glioma specific scorpion toxin==
 
<StructureSection load='7x41' size='340' side='right'caption='[[7x41]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
Authors: Chang, Y.T., Chuang, W.J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7x41]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X41 FirstGlance]. <br>
Description: Crystal structure of chlorotoxin, a glioma specific scorpion toxin
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x41 OCA], [https://pdbe.org/7x41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x41 RCSB], [https://www.ebi.ac.uk/pdbsum/7x41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x41 ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Chang, Y.T]]
== Function ==
[[Category: Chuang, W.J]]
[https://www.uniprot.org/uniprot/CTXL_LEIQU CTXL_LEIQU] This toxin binds to the surface of glioma cells, and inhibits their proliferation without having effects on normal brain cells. In this context, this toxin has been described as a chloride channel inhibitor (probably ClC-3/CLCN3) by causing its internalization via caveolae (PubMed:16520829). It has also been described to selectively interact with MMP2 (in complex with MT1-MMP (MMP14) and TIMP2), to inhibit its enzymatic activity and to decrease its presence at the cell surface (PubMed:12454020).<ref>PMID:12454020</ref> <ref>PMID:16520829</ref> <ref>PMID:8383429</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Leiurus quinquestriatus quinquestriatus]]
[[Category: Chang YT]]
[[Category: Chuang WJ]]
Retrieved from "https://proteopedia.org/7x41"