7xgp: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7xgp is ~~ON HOLD until Paper Publication~~

==Human renin in complex with compound3==

~~Authors~~: ~~Kashima~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[7xgp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XGP FirstGlance]. <br>

~~Description~~: ~~Human renin~~ in ~~complex with compound3~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xgp OCA], [https://pdbe.org/7xgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xgp RCSB], [https://www.ebi.ac.uk/pdbsum/7xgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xgp ProSAT]</span></td></tr>

[[Category: Kashima, A]]

</table>

== Disease ==

[[https://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:[https://omim.org/entry/267430 267430]]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).<ref>PMID:16116425</ref> Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:[https://omim.org/entry/613092 613092]]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.<ref>PMID:19664745</ref>

== Function ==

[[https://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Kashima A]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7xgp is ON HOLD  until Paper Publication
+==Human renin in complex with compound3==
+<StructureSection load='7xgp' size='340' side='right'caption='[[7xgp]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
-Authors: Kashima, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7xgp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XGP FirstGlance]. <br>
-Description: Human renin in complex with compound3
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xgp OCA], [https://pdbe.org/7xgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xgp RCSB], [https://www.ebi.ac.uk/pdbsum/7xgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xgp ProSAT]</span></td></tr>
-[[Category: Kashima, A]]
+</table>
+== Disease ==
+[[https://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:[https://omim.org/entry/267430 267430]]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).<ref>PMID:16116425</ref>   Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:[https://omim.org/entry/613092 613092]]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.<ref>PMID:19664745</ref>
+== Function ==
+[[https://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Kashima A]]