7y87: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 7y87 is ON HOLD  until 2024-06-23
==class I diterpene synthase mutant (CyS-C59A) from Streptomyces cattleya==
<StructureSection load='7y87' size='340' side='right'caption='[[7y87]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7y87]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y87 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y87 OCA], [https://pdbe.org/7y87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y87 RCSB], [https://www.ebi.ac.uk/pdbsum/7y87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y87 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/F8JK18_STREN F8JK18_STREN]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structures of cattleyene synthase (apo-CyS), and CyS complexed with geranylgeranyl pyrophosphate (GGPP) were solved. The CyS(C59A) variant exhibited an increased production of cattleyene and other diterpenes with diverse skeletons. Its structure showed a widened active site cavity explaining the relaxed selectivity. Isotopic labeling experiments revealed a remarkable cyclization mechanism involving several skeletal rearrangements for one of the novel diterpenes.


Authors: Xing, B., Ma, M.
Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes.,Xing B, Xu H, Li A, Lou T, Xu M, Wang K, Xu Z, Dickschat JS, Yang D, Ma M Angew Chem Int Ed Engl. 2022 Sep 5;61(36):e202209785. doi: , 10.1002/anie.202209785. Epub 2022 Aug 1. PMID:35819825<ref>PMID:35819825</ref>


Description: class I diterpene synthase mutant (CyS-C59A) from Streptomyces cattleya
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Xing, B]]
<div class="pdbe-citations 7y87" style="background-color:#fffaf0;"></div>
[[Category: Ma, M]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces cattleya]]
[[Category: Ma M]]
[[Category: Xing B]]
Retrieved from "https://proteopedia.org/7y87"