Function
Flocculation protein or flocculin (FLO) are yeast adhesion protein family involved in cell-cell adhesion via lectin-carbohydrate interaction[1]. FLO1, FLO5, FLO9 and FLO10 have similar sequence and cause formation of cellular clumps (flocs) while FLO11 has unrelated sequence and is required for diploid formation and haploid invasive growth. Flocculins confer calcium-dependent cell-cell adhesion, formation of cellular flocs and protection against environmental stress.
Relevance
The process of flocculation has an important role in the production of beer and wine[2].
Structural highlights
The N-terminal domain of FLO is similar to the lectin-like domain of Adhesin
- ↑ Goossens K, Willaert R. Flocculation protein structure and cell-cell adhesion mechanism in Saccharomyces cerevisiae. Biotechnol Lett. 2010 Nov;32(11):1571-85. doi: 10.1007/s10529-010-0352-3. Epub, 2010 Jul 18. PMID:20640875 doi:https://dx.doi.org/10.1007/s10529-010-0352-3
- ↑ Verstrepen KJ, Derdelinckx G, Verachtert H, Delvaux FR. Yeast flocculation: what brewers should know. Appl Microbiol Biotechnol. 2003 May;61(3):197-205. doi:, 10.1007/s00253-002-1200-8. Epub 2003 Jan 25. PMID:12698276 doi:https://dx.doi.org/10.1007/s00253-002-1200-8
