Glyoxylate cycle: Difference between revisions

From Proteopedia
Jump to navigationJump to search
No edit summary
No edit summary
Line 4: Line 4:
The glyoxylate cycle uses six of the eight enzymes associated with the tricarboxylic acid cycle: citrate synthase, aconitase, succinate dehydrogenase, fumarase, and malate dehydrogenase.
The glyoxylate cycle uses six of the eight enzymes associated with the tricarboxylic acid cycle: citrate synthase, aconitase, succinate dehydrogenase, fumarase, and malate dehydrogenase.


1) [[Citrate Synthase]]
[[Citrate Synthase]]


4C <scene name='43/430893/Cv/3'>oxaloacetate</scene> to a 6C molecule <scene name='43/430893/Cv/4'>citrate</scene>
4C <scene name='43/430893/Cv/3'>oxaloacetate</scene> to a 6C molecule <scene name='43/430893/Cv/4'>citrate</scene>


2) [[Aconitase]]
[[Aconitase]]


6C Citrate => 6C <scene name='43/430893/Cv/5'>cis-Aconitate</scene>
6C Citrate => 6C <scene name='43/430893/Cv/5'>cis-Aconitate</scene>
Line 14: Line 14:
6C ''cis''-Aconitate => 6C <scene name='43/430893/Cv/6'>Isocitrate</scene>
6C ''cis''-Aconitate => 6C <scene name='43/430893/Cv/6'>Isocitrate</scene>


3) [[Succinate Dehydrogenase]]
[[Succinate Dehydrogenase]]


<scene name='43/430893/Cv/10'>Succinate</scene> => <scene name='43/430893/Cv/11'>Fumarate</scene>
<scene name='43/430893/Cv/10'>Succinate</scene> => <scene name='43/430893/Cv/11'>Fumarate</scene>


[[Fumarase]]
   
   
Fumarate => <scene name='43/430893/Cv/12'>L-Malate</scene>


The two cycles differ in that in the glyoxylate cycle, isocitrate is converted into <scene name='93/939250/Cv/1'>glyoxylate</scene> and succinate by isocitrate lyase (ICL) instead of into α-ketoglutarate.
[[Malate dehydrogenase]]
*Step 9 = [[Krebs cycle step 8]]
L-Malate => <scene name='43/430893/Cv/3'>oxaloacetate</scene>
 
The two cycles differ in that in the glyoxylate cycle, <scene name='43/430893/Cv/6'>isocitrate</scene> is converted into <scene name='93/939250/Cv/1'>glyoxylate</scene> and <scene name='43/430893/Cv/10'>Succinate</scene> by isocitrate lyase (ICL) instead of into α-ketoglutarate.


*[[Malate synthase]]
*[[Malate synthase]]

Revision as of 13:01, 28 November 2022

Structure of malate synthase G complex with CoA, malate, Hepes and Mg+2 ion (green) (PDB entry 2gq3)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky