6uzo: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uzo OCA], [https://pdbe.org/6uzo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uzo RCSB], [https://www.ebi.ac.uk/pdbsum/6uzo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uzo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uzo OCA], [https://pdbe.org/6uzo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uzo RCSB], [https://www.ebi.ac.uk/pdbsum/6uzo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uzo ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
[https://www.uniprot.org/uniprot/F4NBQ8_HUMAN F4NBQ8_HUMAN]  


==See Also==
==See Also==
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*[[MHC 3D structures|MHC 3D structures]]
*[[MHC 3D structures|MHC 3D structures]]
*[[MHC I 3D structures|MHC I 3D structures]]
*[[MHC I 3D structures|MHC I 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Latest revision as of 05:52, 21 November 2024

HLA-B*15:02 complexed with a synthetic peptide

6uzo, resolution 2.35Å

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