8r4u: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The entry ~~8r4u is ON HOLD until Paper Publication~~

==Structure of salt-inducible kinase 3 with inhibitors==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8r4u]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8R4U OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8R4U FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.416Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=XW3:8-[(5-azanyl-1,3-dioxan-2-yl)methyl]-6-[2-chloranyl-4-(3-fluoranylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one'>XW3</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8r4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r4u OCA], [https://pdbe.org/8r4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r4u RCSB], [https://www.ebi.ac.uk/pdbsum/8r4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r4u ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/SIK3_HUMAN SIK3_HUMAN] The disease is caused by variants affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/SIK3_HUMAN SIK3_HUMAN] Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).[UniProtKB:Q6P4S6]<ref>PMID:30232230</ref> <ref>PMID:29211348</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Kack H]]

[[Category: Oster L]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8r4u is ON HOLD  until Paper Publication
+==Structure of salt-inducible kinase 3 with inhibitors==
+<StructureSection load='8r4u' size='340' side='right'caption='[[8r4u]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8r4u]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8R4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8R4U FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.416&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=XW3:8-[(5-azanyl-1,3-dioxan-2-yl)methyl]-6-[2-chloranyl-4-(3-fluoranylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one'>XW3</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8r4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r4u OCA], [https://pdbe.org/8r4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r4u RCSB], [https://www.ebi.ac.uk/pdbsum/8r4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r4u ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/SIK3_HUMAN SIK3_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/SIK3_HUMAN SIK3_HUMAN] Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).[UniProtKB:Q6P4S6]<ref>PMID:30232230</ref> <ref>PMID:29211348</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Kack H]]
+[[Category: Oster L]]