7z05: Difference between revisions
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/R1AB_WBV24 R1AB_WBV24] The 3C-like serine proteinase is responsible for the majority of cleavages. | [https://www.uniprot.org/uniprot/R1AB_WBV24 R1AB_WBV24] Catalyzes the RNA N7-guanylyltransferase reaction to methylate the core cap structure GpppN-RNA into the type-0 cap (m)GpppN-RNA.<ref>PMID:36265859</ref> The 3C-like serine proteinase is responsible for the majority of cleavages.<ref>PMID:21068254</ref> The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. The exoribonuclease acts on ssRNA in a 3' to 5' direction (PubMed:30058998). Most active on dsRNA substrates containing one or two non-paired 3'-terminal nucleotides, thereby probably increasing the fidelity of the viral RNA-dependent RNA polymerase by excising RNA 3'-end mismatches during viral RNA replication (PubMed:30058998).<ref>PMID:30058998</ref> NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond. Catalyzes the RNA 2'-O-ribose methyltransferase reaction to methylate the type-0 cap into the type-1 cap (m)GpppN(m)-RNA.[UniProtKB:P0C6X7] | ||
== References == | |||
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</StructureSection> | </StructureSection> | ||
