8rsm: Difference between revisions
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==Crystal structure of Streptococcus pyogenes macrodomain in complex with ADP-ribose== | |||
<StructureSection load='8rsm' size='340' side='right'caption='[[8rsm]], [[Resolution|resolution]] 1.87Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8rsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RSM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rsm OCA], [https://pdbe.org/8rsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rsm RCSB], [https://www.ebi.ac.uk/pdbsum/8rsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rsm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ADPRH_STRP1 ADPRH_STRP1] ADP-ribose glycohydrolase that hydrolyzes ADP-ribosyl-cysteine bonds (By similarity). Specifically reverses the SirTM-mediated mono-ADP-ribosylation of GcvH-L, by releasing ADP-ribose from the target protein. May be involved in the modulation of the response to host-derived oxidative stress.[UniProtKB:P0DN70] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Streptococcus pyogenes]] | |||
[[Category: Ariza A]] | |||
Latest revision as of 05:08, 25 September 2024
Crystal structure of Streptococcus pyogenes macrodomain in complex with ADP-ribose
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