1uk1: Difference between revisions

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[[Image:1uk1.gif|left|200px]]
{{Seed}}
[[Image:1uk1.png|left|200px]]


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{{STRUCTURE_1uk1|  PDB=1uk1  |  SCENE=  }}  
{{STRUCTURE_1uk1|  PDB=1uk1  |  SCENE=  }}  


'''Crystal structure of human poly(ADP-ribose) polymerase complexed with a potent inhibitor'''
===Crystal structure of human poly(ADP-ribose) polymerase complexed with a potent inhibitor===




==Overview==
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A novel class of quinazolinone derivatives as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors has been discovered. Key to success was application of a rational discovery strategy involving structure-based design, combinatorial chemistry, and classical SAR for improvement of potency and bioavailability. The new inhibitors were shown to bind to the nicotinamide-ribose binding site (NI site) and the adenosine-ribose binding site (AD site) of NAD+.
The line below this paragraph, {{ABSTRACT_PUBMED_15293985}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15293985 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15293985}}


==About this Structure==
==About this Structure==
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[[Category: Kinoshita, T.]]
[[Category: Kinoshita, T.]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:20:01 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:14:41 2008''
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