9v14: Difference between revisions

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'''Unreleased structure'''


The entry 9v14 is ON HOLD
==crystal structure of the enzyme-product complex of L-azetidine-2-carboxylate hydrolase==
 
<StructureSection load='9v14' size='340' side='right'caption='[[9v14]], [[Resolution|resolution]] 0.93&Aring;' scene=''>
Authors: Toyoda, M., Mizutani, K., Mikami, B., Wackett, L.P., Esaki, N., Kurihara, T.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9v14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_sp._A2C Pseudomonas sp. A2C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9V14 FirstGlance]. <br>
Description: crystal structure of the enzyme-product complex of L-azetidine-2-carboxylate hydrolase
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.93&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=42B:4-AMINO-2-HYDROXYBUTANOIC+ACID'>42B</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
[[Category: Wackett, L.P]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9v14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v14 OCA], [https://pdbe.org/9v14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v14 RCSB], [https://www.ebi.ac.uk/pdbsum/9v14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v14 ProSAT]</span></td></tr>
[[Category: Esaki, N]]
</table>
[[Category: Mizutani, K]]
== Function ==
[[Category: Kurihara, T]]
[https://www.uniprot.org/uniprot/A2CH_PSEU6 A2CH_PSEU6] Catalyzes the hydrolysis of the toxic natural product azetidine-2-carboxylate (an L-proline analog) by opening the azetidine ring to produce 2-hydroxy-4-aminobutanoate. Is thus involved in the detoxification of this compound but also in the degradation pathway of azetidine-2-carboxylate that allows Pseudomonas sp. A2C to grow on azetidine-2-carboxylate as the sole source of nitrogen. Does not show any detectable 2-haloacid dehalogenase activity with either (R)- or (S)-2-chloropropionate as the substrate, and is not able to hydrolyze L-proline.<ref>PMID:18487339</ref>
[[Category: Mikami, B]]
== References ==
[[Category: Toyoda, M]]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas sp. A2C]]
[[Category: Esaki N]]
[[Category: Kurihara T]]
[[Category: Mikami B]]
[[Category: Mizutani K]]
[[Category: Toyoda M]]
[[Category: Wackett LP]]
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