9v2s: Difference between revisions

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'''Unreleased structure'''


The entry 9v2s is ON HOLD  until Paper Publication
==Cryo-EM structure of Runella bGSDM pore==
 
<StructureSection load='9v2s' size='340' side='right'caption='[[9v2s]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
Authors: Su, Z., Feng, Y., Gan, J.H., Feng, Y.J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9v2s]] is a 92 chain structure with sequence from [https://en.wikipedia.org/wiki/Runella_zeae_DSM_19591 Runella zeae DSM 19591]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9V2S FirstGlance]. <br>
Description: Cryo-EM structure of Runella bGSDM pore
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9v2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v2s OCA], [https://pdbe.org/9v2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v2s RCSB], [https://www.ebi.ac.uk/pdbsum/9v2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v2s ProSAT]</span></td></tr>
[[Category: Gan, J.H]]
</table>
[[Category: Su, Z]]
== Function ==
[[Category: Feng, Y.J]]
[https://www.uniprot.org/uniprot/GSDM_RUNZN GSDM_RUNZN] Precursor of a pore-forming protein involved in defense against bacteriophages (By similarity). Cleavage of this precursor by its dedicated, neighboring protease (G563DRAFT_02009) releases the active moiety (gasdermin bGSDM, N-terminus) which inserts into membranes, forming pores and triggering cell death (PubMed:35025633). Expression of bGSDM and its protease is highly toxic in E.coli (PubMed:35025633). Cells expressing the gene pair stop dividing and lose membrane integrity (PubMed:35025633). Both proteins are required to kill E.coli (PubMed:35025633).[UniProtKB:A0A0S2DNG5]<ref>PMID:35025633</ref>  Pore-forming protein that causes membrane permeabilization via a pyroptosis-like activity (PubMed:35025633). Makes ring-like pores with walls about 50 Angstroms thick and an interior pore diameter of 200-300 Angstroms, when integrated in liposomes (PubMed:35025633, PubMed:38509367).<ref>PMID:35025633</ref> <ref>PMID:38509367</ref>
[[Category: Feng, Y]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Runella zeae DSM 19591]]
[[Category: Feng Y]]
[[Category: Feng YJ]]
[[Category: Gan JH]]
[[Category: Su Z]]
Retrieved from "https://proteopedia.org/9v2s"