9ydk: Difference between revisions
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==Dickerson dodecamer RNA duplex containing a modified base with a 2-F-6-aminopurine/G mismatch.== | |||
<StructureSection load='9ydk' size='340' side='right'caption='[[9ydk]], [[Resolution|resolution]] 1.12Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ydk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YDK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.12Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CU1:[(2~{R},3~{S},4~{R},5~{R})-5-(6-azanyl-2-fluoranyl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl+dihydrogen+phosphate'>A1CU1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ydk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ydk OCA], [https://pdbe.org/9ydk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ydk RCSB], [https://www.ebi.ac.uk/pdbsum/9ydk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ydk ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We describe a strategy for the synthesis of DNA, RNA and 2'-O-methyl (2'-O-Me) oligonucleotides containing 2-fluoro-adenine (A(F)) and isoguanine (iG) nucleobases. To the best of our knowledge, this is the first nonenzymatic route for the synthesis of oligonucleotides containing 2-fluoro-adenine. We also describe the hydrolytic strategy for the conversion of 2-fluoro-adenine into isoguanine. Unlike 2,6-diaminopurine, 2-fluoro-adenine and isoguanine modifications are thermally destabilizing in the context of DNA, RNA, and 2'-O-methyl oligonucleotide duplexes. | |||
A Postsynthetic Strategy for Oligonucleotides Containing 2-Fluoro-adenine and Isoguanine Nucleobases.,Madaoui M, Kundu J, Datta D, Harp JM, Egli M, Manoharan M Org Lett. 2026 Jul 24;28(29):9133-9138. doi: 10.1021/acs.orglett.6c01203. Epub , 2026 Jul 15. PMID:42455745<ref>PMID:42455745</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 9ydk" style="background-color:#fffaf0;"></div> | ||
[[Category: Egli | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Egli M]] | |||
[[Category: Harp JM]] | |||
Latest revision as of 07:28, 5 August 2026
Dickerson dodecamer RNA duplex containing a modified base with a 2-F-6-aminopurine/G mismatch.
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