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'''Unreleased structure'''


The entry 9pn4 is ON HOLD  until 2027-07-19
==Crystal structure of a three finger toxin from snake venom==
 
<StructureSection load='9pn4' size='340' side='right'caption='[[9pn4]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
Authors: Jobichen, C., Christabel, C.Y.L., Sivaraman, J., Kini, R.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9pn4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PN4 FirstGlance]. <br>
Description: Crystal structure of a three finger toxin from snake venom
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Jobichen, C]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9pn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9pn4 OCA], [https://pdbe.org/9pn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9pn4 RCSB], [https://www.ebi.ac.uk/pdbsum/9pn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9pn4 ProSAT]</span></td></tr>
[[Category: Christabel, C.Y.L]]
</table>
[[Category: Sivaraman, J]]
== Function ==
[[Category: Kini, R.M]]
[https://www.uniprot.org/uniprot/3SX1_OPHHA 3SX1_OPHHA] This toxin binds and inhibits rat muscle adult alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE (IC(50)=3.1 uM) and fetal alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND (IC(50)=5.6 uM) nicotinic acetylcholine receptors (nAChR) (PubMed:26448325). Shows a very low inhibition on rat neuronal alpha-3-beta-2/CHRNA3-CHRNB2 nAChR (IC(50)=50.2 uM) nAChR (PubMed:26448325). Binds to the acetylcholine-binding pocket and acts as a competitive antagonist (PubMed:26448325). Does not inhibit human glycine receptor (homopentamer composed of alpha-1 subunits, GLRA1), but seems to potentiate it (about 2-fold increased activity) (PubMed:26448325).<ref>PMID:12056805</ref> <ref>PMID:26448325</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Ophiophagus hannah]]
[[Category: Christabel CYL]]
[[Category: Jobichen C]]
[[Category: Kini RM]]
[[Category: Sivaraman J]]
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