9t64: Difference between revisions
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==Cytoplasmic lattice filament repeat unit with the central FBXW-SKP1 complex== | |||
<StructureSection load='9t64' size='340' side='right'caption='[[9t64]], [[Resolution|resolution]] 7.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9t64]] is a 55 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9T64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9T64 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.3Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9t64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9t64 OCA], [https://pdbe.org/9t64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9t64 RCSB], [https://www.ebi.ac.uk/pdbsum/9t64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9t64 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KHDC3_MOUSE KHDC3_MOUSE] Required for maintenance of euploidy during cleavage-stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. Capable of binding RNA.<ref>PMID:19376971</ref> <ref>PMID:22276159</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Carter AP]] | |||
[[Category: Harasimov K]] | |||
[[Category: Singh K]] | |||
Latest revision as of 05:02, 13 August 2026
Cytoplasmic lattice filament repeat unit with the central FBXW-SKP1 complex
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