10ll: Difference between revisions
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==Native flagellar filament from Leptospira interrogans flaB1- KO mutant strain== | |||
<StructureSection load='10ll' size='340' side='right'caption='[[10ll]], [[Resolution|resolution]] 4.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[10ll]] is a 142 chain structure with sequence from [https://en.wikipedia.org/wiki/Leptospira_interrogans Leptospira interrogans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=10LL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=10LL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=10ll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=10ll OCA], [https://pdbe.org/10ll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=10ll RCSB], [https://www.ebi.ac.uk/pdbsum/10ll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=10ll ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q72RA0_LEPIC Q72RA0_LEPIC] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Spirochaete pathogens are among the most invasive bacteria known, causing syphilis, Lyme disease, and leptospirosis. Their tissue penetration depends on periplasmic flagellar filaments that, unlike other bacterial flagella, are encased in a spirochaete-specific multi-protein sheath and deform the cell body into motile waves. How these filaments achieve the mechanical properties needed for invasive motility has remained unclear. Here we determine complete atomic structures of the Leptospira endoflagellar filament, revealing an elaborate sheath of 9 to 12 distinct asymmetrically arranged proteins. We show that the flagellin variant forming the filament core determines sheath composition, producing curvatures ranging from ~3.5 microm(-1) to ~5.6 microm(-1). The lower-curvature architecture, employed by pathogenic Leptospira interrogans, proves essential for motility in viscous environments and during infection. Thus, Leptospira achieves environment-specific motility through modular core-sheath coupling, linking atomic-scale structural plasticity to large-scale changes in swimming behaviour. Conservation of key sheath components suggests this mechanism may extend across spirochaetes. | |||
Core-sheath coupling controls flagellar curvature and motility in Leptospira.,San Martin F, Brady MR, Fule L, Nouchikian L, Rodriguez A, Duchateau M, Mondino S, Larrieux N, Wunder EA Jr, Ko AI, Rey M, Chamot-Rooke J, Duran R, Trajtenberg F, Picardeau M, Sindelar CV, Buschiazzo A Nat Commun. 2026 Jul 25;17(1):9075. doi: 10.1038/s41467-026-75995-6. PMID:42649215<ref>PMID:42649215</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 10ll" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: Buschiazzo | <references/> | ||
[[Category: Sindelar | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Leptospira interrogans]] | |||
[[Category: Brady MR]] | |||
[[Category: Buschiazzo A]] | |||
[[Category: San Martin F]] | |||
[[Category: Sindelar CV]] | |||
Latest revision as of 16:36, 8 September 2026
Native flagellar filament from Leptospira interrogans flaB1- KO mutant strain
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