11lq: Difference between revisions
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==Human monoclonal antibodies 4C12 and 4H3 in complex with rabies virus glycoprotein== | |||
<StructureSection load='11lq' size='340' side='right'caption='[[11lq]], [[Resolution|resolution]] 3.24Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[11lq]] is a 21 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rabies_lyssavirus Rabies lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=11LQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=11LQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.24Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=11lq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=11lq OCA], [https://pdbe.org/11lq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=11lq RCSB], [https://www.ebi.ac.uk/pdbsum/11lq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=11lq ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GLYCO_RABVP GLYCO_RABVP] Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Rabies lyssavirus]] | |||
[[Category: Bouhry H]] | |||
[[Category: Callaway HM]] | |||
[[Category: Corti D]] | |||
[[Category: Dessain S]] | |||
[[Category: Flynn A]] | |||
[[Category: Hariharan C]] | |||
[[Category: Harkins S]] | |||
[[Category: Hastie K]] | |||
[[Category: Kothalawalage S]] | |||
[[Category: Samarasinghe S]] | |||
[[Category: Saphire EO]] | |||
[[Category: Yin J]] | |||
[[Category: Zyla D]] | |||
Latest revision as of 04:53, 19 August 2026
Human monoclonal antibodies 4C12 and 4H3 in complex with rabies virus glycoprotein
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