P53 3D structures

• p53 DNA-binding domain (residues 94-292)

• • 2ocj, 2xwr, 2ybg, 8f2i – h-p53 DBD – human
    
  • 2fej - h-p53 DBD - NMR
    
  • 1uol, 2bim, 2bin, 2bio, 2bip, 2biq, 2j1w, 2j1x, 2j1y, 2j1z, 2j20, 2j21, 2pcx, 2wgx, 3d05, 3d06, 3d07, 3d08, 3d09, 4ibq, 4ibs, 4ibt, 4iby, 4ibz, 4ijt, 4kvp, 4lo9, 4loe, 4lof, 4mzi, 5lap, 6ff9, 6shz, 6si0, 6si1, 6sl6, 7dhy, 7dhz, 7eax, 7eeu, 7v97, 8cg7, 8e7a, 8e7b, 8qwk, 8qwl, 8qwm, 8qwn, 8qwo, 8qwp - h-p53 DBD (mutant)
    
  • 1hu8, 2ioi, 2ioo – m-p53 DBD – mouse
    
  • 1t4w – p53-like DBD – Caenoharbditis elegans

• p53 DNA-binding domain complex with DNA

• • 1tsr, 1tup, 2ac0, 2ady, 2ahi, 2ata, 3igk, 3igl, 3kmd, 3kz8, 4hje, 5bua, 5mct, 5mcu, 5mcw, 5lgy, 5mf7, 5mg7, 6fj5 – h-p53 DBD + DNA
    
  • 3d0a, 3ts8, 4ibu, 4ibv, 4ibw, 7b46, 7b47, 7b48, 7b49, 7b4a, 7b4b, 7b4c, 7b4d, 7b4e, 7b4f, 7b4h, 7b4n, 7eds - h-p53 DBD (mutant) + DNA
    
  • 3q05, 3q06 - h-p53 DBD + TD + DNA
    
  • 2geq, 2p52, 3exj, 3exl – m-p53 DBD + DNA

• p53 DNA-binding domain complex with small molecule

• • 2x0u, 2x0v, 2x0w, 4agl, 4agm, 4agn, 4ago, 4agp, 4agq, 5aoj, 5aol – h-p53 DBD (mutant) + benzene derivative
    
  • 3zme, 8a92, 8rbc, 9g5h, 9g5u, 9g6t - h-p53 DBD (mutant) + pyrazol derivative
    
  • 8rba, 8rbb - h-p53 DBD (mutant) + pyridine derivative
    
  • 8dc4 - h-p53 DBD (mutant) + carbazole
    
  • 5ab9, 5aoi, 8dc6, 8dc7, 8dc8 - h-p53 DBD (mutant) + indole derivative
    
  • 2vuk - h-p53 DBD + drug
    
  • 5a7b, 5aba, 5aok, 5aom, 5g4m, 5g4n, 5g4o, 5o1a, 5o1b, 5o1c, 5o1d, 5o1e, 5o1f, 5o1g, 5o1h, 5o1i - h-p53 DBD (mutant) + drug
    
  • 6gff, 6gga, 6ggb, 6ggc, 6ggd, 6gge, 6si3, 6si4, 8a31, 8a32 - h-p53 DBD (mutant) + stabilizer
    
  • 2iom - m-p53 DBD + propanol

• p53 DNA-binding domain complex with protein
  

• • 2k8f – h-p53 residues 1-39 + histone acetyltransferase (mutant) – NMR
    
  • 2h1l - h-p53 DBD + large T antigen
    
  • 1ycs - h-p53 DBD + 53BP2
    
  • 1gzh, 1kzy - h-p53 DBD + tumor suppressor p53-binding protein
    
  • 4xr8 - h-p53 DBD + E6 + E6AP
    
  • 4qo1 - h-p53 DBD + nanobody
    
  • 6rz3 - h-p53 DBD + IASPP
    
  • 7dvd - h-p53 DBD + PUMA
    
  • 8hll, 8hlm, 8hln - h-p53 DBD + Bcl-2
    
  • 7ygi - h-p53 DBD + azurin
    
  • 8fzb, 8rci - h-p53 DBD + darpin
    
  • 8j8n - h-p53 DBD + zinc finger protein – Cryo EM
    
• p53 transactivation domain (residues 15-29)

• • 2z5s, 2z5t - h-p53 TAD + MDM4 protein
    
  • 1ycq, 1ycr - h-p53 TAD + MDM2 protein
    
  • 2l14 – h-p53 TAD + CREB-binding protein
    
  • 2gs0 – h-p53 TAD + RNA polymerase II transcription factor
    
  • 7nmi - h-p53 TAD + S110P/ANXA2
    

• p53 tetramerization domain (residues 326-356)

• • 1hs5, 1olg, 1pes, 1pet, 1sae, 1saf, 1sak, 1sal, 2j0z, 3sak – h-p53 TD – NMR
    
  • 1aie, 1c26, 8uqr - h-p53 TD
    
  • 1a1u, 2j10, 2j11 - h-p53 TD (mutant) – NMR
    
  • 7bwn - h-p53 TD + GFP
    
  • 8uqs - p53 TD - opossum
    
  • 8uqt - p53 TD - shrew
    
• p53 tetramerization+DBD domains

• • 3q01, 4mzr – h-p53 + DNA
    
  • 5xzc – h-p53 + P300 – Cryo EM
    

• p53 full (residues 1-393)

• • 8wd2, 8xcb, 8xce – h-p53
    
  • 9s9r – h-p53 (mutant)
    
  • 6xre – h-p53 + RNA polymerase II – Cryo EM
    
  • 8r1f, 8r1g , 8zzn– h-p53 + ubiquitin protein ligase E3A + E6 – Cryo EM
    
  • 9br3, 9br4 – h-p53 + drug
    
  • 9s9l, 9s9m, 9s9n, 9s9o, 9s9p, 9s9q – h-p53 (mutant) + drug
    

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Michal Harel, Jaime Prilusky