2npa: Difference between revisions

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[[Image:2npa.gif|left|200px]]
{{Seed}}
[[Image:2npa.png|left|200px]]


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{{STRUCTURE_2npa|  PDB=2npa  |  SCENE=  }}  
{{STRUCTURE_2npa|  PDB=2npa  |  SCENE=  }}  


'''the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid'''
===the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid===




==Overview==
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Oxime ethers of alpha-acyl-beta-phenylpropanoic acids were prepared to apply as PPARalpha and gamma dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC(50) of 19 and 13nM in PPARalpha and gamma, respectively. It showed better glucose lowering effects than rosiglitazone 1 and ameliorated the lipid profile like plasma triglyceride in db/db mice model.
The line below this paragraph, {{ABSTRACT_PUBMED_17157019}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17157019 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17157019}}


==About this Structure==
==About this Structure==
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[[Category: Protein-agonist complex]]
[[Category: Protein-agonist complex]]
[[Category: Transcription]]
[[Category: Transcription]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:44:11 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:46:35 2008''
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