1tip: Difference between revisions
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New page: left|200px<br /><applet load="1tip" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tip, resolution 2.2Å" /> '''THE BISPHOSPHATASE DO... |
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[[Image:1tip.jpg|left|200px]]<br /><applet load="1tip" size=" | [[Image:1tip.jpg|left|200px]]<br /><applet load="1tip" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1tip, resolution 2.2Å" /> | caption="1tip, resolution 2.2Å" /> | ||
'''THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE'''<br /> | '''THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of the fructose-2,6-bisphosphatase domain trapped | The crystal structure of the fructose-2,6-bisphosphatase domain trapped during the reaction reveal a phosphorylated His 258, and a water molecule immobilized by the product, fructose-6-phosphate. The geometry suggests that the dephosphorylation step requires prior removal of the product for an 'associative in-line' phosphoryl transfer to the catalytic water. | ||
==About this Structure== | ==About this Structure== | ||
1TIP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with F6P as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Fructose-2,6-bisphosphate_2-phosphatase Fructose-2,6-bisphosphate 2-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.46 3.1.3.46] Full crystallographic information is available from [http:// | 1TIP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=F6P:'>F6P</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Fructose-2,6-bisphosphate_2-phosphatase Fructose-2,6-bisphosphate 2-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.46 3.1.3.46] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIP OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Banaszak, L | [[Category: Banaszak, L J.]] | ||
[[Category: Lange, A | [[Category: Lange, A J.]] | ||
[[Category: Lee, Y | [[Category: Lee, Y H.]] | ||
[[Category: Levitt, D | [[Category: Levitt, D G.]] | ||
[[Category: Ogata, C | [[Category: Ogata, C M.]] | ||
[[Category: Olson, T | [[Category: Olson, T W.]] | ||
[[Category: F6P]] | [[Category: F6P]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:13:57 2008'' | ||
