1h6v: Difference between revisions

Revision as of 23:00, 14 March 2011

Ligands:

FAD, NDP

Non-Standard Residues:

SEL

Activity:

Thioredoxin-disulfide reductase, with EC number 1.8.1.9

Structural annotation:

Resources:

Functional annotation:
Cellular component:	cytosol cytoplasm
Biological process:	cell proliferation electron transport response to oxidative stress hydrogen peroxide catabolic process cell redox homeostasis thioredoxin pathway
Molecular function:	NADP binding FAD binding thioredoxin-disulfide reductase activity oxidoreductase activity selenium binding oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

1h6v is a 6 chain structure of Thioredoxin Reductase with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Sandalova T, Zhong L, Lindqvist Y, Holmgren A, Schneider G. Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9533-8. Epub 2001 Jul 31. PMID:11481439 doi:10.1073/pnas.171178698
Zhong L, Persson K, Sandalova T, Schneider G, Holmgren A. Purification, crystallization and preliminary crystallographic data for rat cytosolic selenocysteine 498 to cysteine mutant thioredoxin reductase. Acta Crystallogr D Biol Crystallogr. 2000 Sep;56(Pt 9):1191-3. PMID:10957643

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-{{Seed}}
 [[Image:1h6v.png|left|200px]]
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 ==About this Structure==
-H6V is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6V OCA].
+[[1h6v]] is a 6 chain structure of [[Thioredoxin Reductase]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6V OCA].
+==See Also==
+*[[Thioredoxin Reductase]]
+*[[User:Sarah Abdalla/Thioredoxin Reductase]]
 ==Reference==
-<ref group="xtra">PMID:11481439</ref><references group="xtra"/>
+<ref group="xtra">PMID:11481439</ref><ref group="xtra">PMID:10957643</ref><references group="xtra"/>
 [[Category: Rattus norvegicus]]
 [[Category: Thioredoxin-disulfide reductase]]
@@ Line 32: / Line 35: @@
 [[Category: Zhong, L.]]
 [[Category: Flavoprotein]]
+[[Category: Oxidoreductase]]
 [[Category: Pyridine nucleotide-disulfide oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:24:56 2009''