2f54: Difference between revisions

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{{Seed}}
[[Image:2f54.png|left|200px]]
[[Image:2f54.png|left|200px]]


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{{STRUCTURE_2f54|  PDB=2f54  |  SCENE=  }}  
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===Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity===
===Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity===


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{{ABSTRACT_PUBMED_16600963}}
{{ABSTRACT_PUBMED_16600963}}


==Disease==
==About this Structure==
Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109700 109700]]
[[2f54]] is a 10 chain structure of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F54 OCA].


==About this Structure==
==See Also==
2F54 is a 10 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F54 OCA].
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Major histocompatibility complex|Major histocompatibility complex]]


==Reference==
==Reference==
<ref group="xtra">PMID:16600963</ref><references group="xtra"/>
<ref group="xtra">PMID:016600963</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Dunn, S M.]]
[[Category: Dunn, S M.]]
Line 34: Line 23:
[[Category: Cdr2]]
[[Category: Cdr2]]
[[Category: High affinity]]
[[Category: High affinity]]
[[Category: Immune system]]
[[Category: Ny-eso-1]]
[[Category: Ny-eso-1]]
[[Category: Phage display]]
[[Category: Phage display]]
[[Category: T-cell receptor]]
[[Category: T-cell receptor]]
[[Category: Wild type sequence]]
[[Category: Wild type sequence]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:54:42 2009''

Revision as of 11:16, 27 July 2012

File:2f54.png

Template:STRUCTURE 2f54

Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity

Template:ABSTRACT PUBMED 16600963

About this Structure

2f54 is a 10 chain structure of Beta-2 microglobulin and Major histocompatibility complex with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Dunn SM, Rizkallah PJ, Baston E, Mahon T, Cameron B, Moysey R, Gao F, Sami M, Boulter J, Li Y, Jakobsen BK. Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity. Protein Sci. 2006 Apr;15(4):710-21. PMID:16600963 doi:15/4/710

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