Severin

Crystal Structure of Human Severin, 3fg6

Severin is a calcium-activated protein which binds actin. The images at the top and at the right correspond to one representative severin structure, i.e. the human severin (3fg6). It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. It is named Adseverin and Scinderin as well. The image at the right is the severin with calcium ions (colored lime).

3D Structures of Severin

3fg6 – Adseverin C-terminal – human
1svy – Severin domain 2 – Dictyostelium discoideum
1svq - Severin domain 2 - Dictyostelium discoideum, NMR

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Michal Harel