Factor VIII: Difference between revisions
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{{STRUCTURE_2r7e| PDB=2r7e | SIZE=300| SCENE=Factor_VIII/Cv/1 |right|CAPTION=Human Factor VIII, [[2r7e]] }} | {{STRUCTURE_2r7e| PDB=2r7e | SIZE=300| SCENE=Factor_VIII/Cv/1 |right|CAPTION=Human Factor VIII, [[2r7e]] }} | ||
[[Factor VIII]] (FVIII) is a blood clotting factor. Defects in the protein result in hemophilia A. FVIII is a cofactor for factor IXa. The images at the left and at the right correspond to one representative FVIII, ''i.e.'' the crystal structure of | [[Factor VIII]] (FVIII) is a blood clotting factor. Defects in the protein result in hemophilia A. FVIII is a cofactor for factor IXa. The images at the left and at the right correspond to one representative FVIII, ''i.e.'' the crystal structure of human Factor VIII ([[2r7e]]). | ||
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Revision as of 08:52, 2 June 2011
Factor VIII (FVIII) is a blood clotting factor. Defects in the protein result in hemophilia A. FVIII is a cofactor for factor IXa. The images at the left and at the right correspond to one representative FVIII, i.e. the crystal structure of human Factor VIII (2r7e).
3D Structures of Factor VIII
2r7e, 3cdz – hFVIII – human
3hnb, 3hny, 3hob – hFVIII light chain C2 domain
1d7p - hFVIII light chain C2 domain (mutant)
1cfg, 1fac - hFVIII light chain C2 domain membrane-binding peptide - NMR
1iqd - hFVIII light chain C2 domain (mutant) + monoclonal Fab
