Sphingomyelinase: Difference between revisions
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{{STRUCTURE_2dds| PDB=2dds | SIZE=400| SCENE= |right|CAPTION=Sphingomyelin complex with cobalt ion [[2dds]] }} | |||
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Revision as of 12:03, 12 March 2012
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| Sphingomyelin complex with cobalt ion 2dds | |||||||||||||
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| Ligands: | CO | ||||||||||||
| Activity: | Sphingomyelin phosphodiesterase, with EC number 3.1.4.12 | ||||||||||||
| Related: | 2ddr, 2ddt | ||||||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB, TOPSAN | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Sphingomyelinase (SMase) is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and ceramide. The SMase is classified into 5 types according to their pH dependence and cation dependence.
3D structures of sphingomyelinase
3rlh, 3rlg – SMase D (mutant) – Loxosceles intermedia
1xx1, 2f9r – SMase I – Loxosceles laeta
1zwx – SMase C – Listeria ivanovii
2ddr, 2dds, 2ddt – BcSMase + cation – Bacillus cereus
2uyr – BcSMase (mutant)
