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{{Seed}}
[[Image:1py2.png|left|200px]]
[[Image:1py2.png|left|200px]]


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{{STRUCTURE_1py2|  PDB=1py2  |  SCENE=  }}  
{{STRUCTURE_1py2|  PDB=1py2  |  SCENE=  }}  


===Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2===
===Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2===


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The line below this paragraph, {{ABSTRACT_PUBMED_14664558}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_14664558}}
{{ABSTRACT_PUBMED_14664558}}


==Disease==
==About this Structure==
Known disease associated with this structure: Severe combined immunodeficiency due to IL2 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147680 147680]]
[[1py2]] is a 4 chain structure of [[Interleukin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PY2 OCA].


==About this Structure==
==See Also==
1PY2 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PY2 OCA].
*[[Interleukin|Interleukin]]


==Reference==
==Reference==
<ref group="xtra">PMID:14664558</ref><references group="xtra"/>
<ref group="xtra">PMID:014664558</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Randal, M.]]
[[Category: Randal, M.]]
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[[Category: Hot spot]]
[[Category: Hot spot]]
[[Category: Il-2]]
[[Category: Il-2]]
[[Category: Immune system]]
[[Category: Interleukin 2]]
[[Category: Interleukin 2]]
[[Category: Molecular recognition]]
[[Category: Molecular recognition]]
[[Category: Small molecule]]
[[Category: Small molecule]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:54:58 2009''

Revision as of 02:32, 26 July 2012

File:1py2.png

Template:STRUCTURE 1py2

Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2

Template:ABSTRACT PUBMED 14664558

About this Structure

1py2 is a 4 chain structure of Interleukin with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Thanos CD, Randal M, Wells JA. Potent small-molecule binding to a dynamic hot spot on IL-2. J Am Chem Soc. 2003 Dec 17;125(50):15280-1. PMID:14664558 doi:10.1021/ja0382617

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