1h6v: Difference between revisions

Revision as of 22:48, 26 July 2012

Ligands:

FAD, NDP

Non-Standard Residues:

SEL

Activity:

Thioredoxin-disulfide reductase, with EC number 1.8.1.9

Structural annotation:

Resources:

Functional annotation:
Cellular component:	cytosol cytoplasm
Biological process:	cell proliferation electron transport response to oxidative stress hydrogen peroxide catabolic process cell redox homeostasis thioredoxin pathway
Molecular function:	NADP binding FAD binding thioredoxin-disulfide reductase activity oxidoreductase activity selenium binding oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

1h6v is a 6 chain structure of Thioredoxin Reductase with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Sandalova T, Zhong L, Lindqvist Y, Holmgren A, Schneider G. Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9533-8. Epub 2001 Jul 31. PMID:11481439 doi:10.1073/pnas.171178698
Zhong L, Persson K, Sandalova T, Schneider G, Holmgren A. Purification, crystallization and preliminary crystallographic data for rat cytosolic selenocysteine 498 to cysteine mutant thioredoxin reductase. Acta Crystallogr D Biol Crystallogr. 2000 Sep;56(Pt 9):1191-3. PMID:10957643

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 [[Image:1h6v.png|left|200px]]
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 {{STRUCTURE_1h6v|  PDB=1h6v  |  SCENE=  }}
 ===MAMMALIAN THIOREDOXIN REDUCTASE===
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 ==See Also==
-*[[Thioredoxin Reductase]]
+*[[Thioredoxin Reductase|Thioredoxin Reductase]]
-*[[User:Sarah Abdalla/Thioredoxin Reductase]]
 ==Reference==
-<ref group="xtra">PMID:11481439</ref><ref group="xtra">PMID:10957643</ref><references group="xtra"/>
+<ref group="xtra">PMID:011481439</ref><ref group="xtra">PMID:010957643</ref><references group="xtra"/>
 [[Category: Rattus norvegicus]]
 [[Category: Thioredoxin-disulfide reductase]]