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==Overview==

Desmosomes are intercellular junctions in which cadherin cell adhesion, molecules are linked to the intermediate filament (IF) system. Desmoplakin, is a member of the plakin family of IF-binding proteins. The C-terminal, domain of desmoplakin (DPCT) mediates binding to IFs in desmosomes. The, DPCT sequence contains three regions, termed A, B and C, consisting of 4.5, copies of a 38-amino acid repeat motif. We demonstrate that these regions, form discrete subdomains that bind to IFs and report the crystal, structures of domains B and C. In contrast to the elongated structures, formed by other kinds of repeat motifs, the plakin repeats form a globular, structure with a unique fold. A conserved basic groove found on the domain, may represent an IF-binding site.

Desmosomes are intercellular junctions in which cadherin cell adhesion molecules are linked to the intermediate filament (IF) system. Desmoplakin is a member of the plakin family of IF-binding proteins. The C-terminal domain of desmoplakin (DPCT) mediates binding to IFs in desmosomes. The DPCT sequence contains three regions, termed A, B and C, consisting of 4.5 copies of a 38-amino acid repeat motif. We demonstrate that these regions form discrete subdomains that bind to IFs and report the crystal structures of domains B and C. In contrast to the elongated structures formed by other kinds of repeat motifs, the plakin repeats form a globular structure with a unique fold. A conserved basic groove found on the domain may represent an IF-binding site.

==Disease==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Choi, H.J.]]

[[Category: Choi, H J.]]

[[Category: Green, K.J.]]

[[Category: Green, K J.]]

[[Category: Park-Snyder, S.]]

[[Category: Pascoe, L.T.]]

[[Category: Pascoe, L T.]]

[[Category: Weis, W.I.]]

[[Category: Weis, W I.]]

[[Category: plakin repeat]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:46:13 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Desmosomes are intercellular junctions in which cadherin cell adhesion, molecules are linked to the intermediate filament (IF) system. Desmoplakin, is a member of the plakin family of IF-binding proteins. The C-terminal, domain of desmoplakin (DPCT) mediates binding to IFs in desmosomes. The, DPCT sequence contains three regions, termed A, B and C, consisting of 4.5, copies of a 38-amino acid repeat motif. We demonstrate that these regions, form discrete subdomains that bind to IFs and report the crystal, structures of domains B and C. In contrast to the elongated structures, formed by other kinds of repeat motifs, the plakin repeats form a globular, structure with a unique fold. A conserved basic groove found on the domain, may represent an IF-binding site.
+Desmosomes are intercellular junctions in which cadherin cell adhesion molecules are linked to the intermediate filament (IF) system. Desmoplakin is a member of the plakin family of IF-binding proteins. The C-terminal domain of desmoplakin (DPCT) mediates binding to IFs in desmosomes. The DPCT sequence contains three regions, termed A, B and C, consisting of 4.5 copies of a 38-amino acid repeat motif. We demonstrate that these regions form discrete subdomains that bind to IFs and report the crystal structures of domains B and C. In contrast to the elongated structures formed by other kinds of repeat motifs, the plakin repeats form a globular structure with a unique fold. A conserved basic groove found on the domain may represent an IF-binding site.
 ==Disease==
@@ Line 16: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Choi, H.J.]]
+[[Category: Choi, H J.]]
-[[Category: Green, K.J.]]
+[[Category: Green, K J.]]
 [[Category: Park-Snyder, S.]]
-[[Category: Pascoe, L.T.]]
+[[Category: Pascoe, L T.]]
-[[Category: Weis, W.I.]]
+[[Category: Weis, W I.]]
 [[Category: plakin repeat]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:19:11 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:46:13 2008''