3lb6: Difference between revisions
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{{STRUCTURE_3lb6| PDB=3lb6 | SCENE= }} | {{STRUCTURE_3lb6| PDB=3lb6 | SCENE= }} | ||
===The structure of IL-13 in complex with IL-13Ralpha2=== | |||
{{ABSTRACT_PUBMED_20223216}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[http://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/A8K7E2_HUMAN A8K7E2_HUMAN]] Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).<ref>PMID:20223216</ref> [[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. | |||
==About this Structure== | ==About this Structure== | ||
| Line 15: | Line 17: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020223216</ref><references group="xtra"/> | <ref group="xtra">PMID:020223216</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Birnbaum, M E.]] | [[Category: Birnbaum, M E.]] | ||
Revision as of 18:49, 24 March 2013
The structure of IL-13 in complex with IL-13Ralpha2
Template:ABSTRACT PUBMED 20223216
Disease
[IL13_HUMAN] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
Function
[A8K7E2_HUMAN] Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).[1] [IL13_HUMAN] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
About this Structure
3lb6 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Lupardus PJ, Birnbaum ME, Garcia KC. Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Structure. 2010 Mar 10;18(3):332-42. PMID:20223216 doi:10.1016/j.str.2010.01.003
- ↑ Lupardus PJ, Birnbaum ME, Garcia KC. Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Structure. 2010 Mar 10;18(3):332-42. PMID:20223216 doi:10.1016/j.str.2010.01.003
