2nw4: Difference between revisions
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{{STRUCTURE_2nw4| PDB=2nw4 | SCENE= }} | {{STRUCTURE_2nw4| PDB=2nw4 | SCENE= }} | ||
===Crystal Structure of the Rat Androgen Receptor Ligand Binding Domain Complex with BMS-564929=== | |||
{{ABSTRACT_PUBMED_17008401}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/ANDR_RAT ANDR_RAT]] Note=Defects in Ar are a cause of androgen insensitivity. Rats with this syndrome are called testicular feminized (TFM).<ref>PMID:2341409</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ANDR_RAT ANDR_RAT]] Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity).<ref>PMID:17181141</ref><ref>PMID:17008401</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017008401</ref><references group="xtra"/> | <ref group="xtra">PMID:017008401</ref><references group="xtra"/><references/> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: An, Y.]] | [[Category: An, Y.]] | ||
