3g3d: Difference between revisions
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{{STRUCTURE_3g3d| PDB=3g3d | SCENE= }} | {{STRUCTURE_3g3d| PDB=3g3d | SCENE= }} | ||
===Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-azido-UMP=== | ===Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-azido-UMP=== | ||
{{ABSTRACT_PUBMED_19260677}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/PYR5_HUMAN PYR5_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019260677</ref><references group="xtra"/> | <ref group="xtra">PMID:019260677</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Orotidine-5'-phosphate decarboxylase]] | [[Category: Orotidine-5'-phosphate decarboxylase]] | ||
Revision as of 01:40, 25 March 2013
Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-azido-UMP
Template:ABSTRACT PUBMED 19260677
Disease
[PYR5_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.[1]
About this Structure
3g3d is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Bello AM, Konforte D, Poduch E, Furlonger C, Wei L, Liu Y, Lewis M, Pai EF, Paige CJ, Kotra LP. Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52(6):1648-58. PMID:19260677 doi:10.1021/jm801224t
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Orotidine-5'-phosphate decarboxylase
- Bello, A.
- Kotra, L.
- Liu, Y.
- Pai, E.
- Poduch, E.
- Tang, H L.
- 5-fluoro-6-azido-ump
- C-terminal domain
- Decarboxylase
- Disease mutation
- Glycosyltransferase
- Human
- Lyase
- Multifunctional enzyme
- Orotidine 5'-monophosphate decarboxylase
- Phosphoprotein
- Pyrimidine biosynthesis
- Transferase
- Ump synthase
