3c6m: Difference between revisions
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{{STRUCTURE_3c6m| PDB=3c6m | SCENE= }} | {{STRUCTURE_3c6m| PDB=3c6m | SCENE= }} | ||
===Crystal structure of human spermine synthase in complex with spermine and 5-methylthioadenosine=== | |||
{{ABSTRACT_PUBMED_18367445}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/SPSY_HUMAN SPSY_HUMAN]] Defects in SMS are the cause of X-linked syndromic mental retardation Snyder-Robinson type (MRXSSR) [MIM:[http://omim.org/entry/309583 309583]]. Characterized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry. Transmission is X-linked recessive.<ref>PMID:14508504</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SPSY_HUMAN SPSY_HUMAN]] Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018367445</ref><references group="xtra"/> | <ref group="xtra">PMID:018367445</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Spermine synthase]] | [[Category: Spermine synthase]] | ||
Revision as of 02:39, 25 March 2013
Crystal structure of human spermine synthase in complex with spermine and 5-methylthioadenosine
Template:ABSTRACT PUBMED 18367445
Disease
[SPSY_HUMAN] Defects in SMS are the cause of X-linked syndromic mental retardation Snyder-Robinson type (MRXSSR) [MIM:309583]. Characterized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry. Transmission is X-linked recessive.[1]
Function
[SPSY_HUMAN] Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).
About this Structure
3c6m is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Wu H, Min J, Zeng H, McCloskey DE, Ikeguchi Y, Loppnau P, Michael AJ, Pegg AE, Plotnikov AN. Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J Biol Chem. 2008 Jun 6;283(23):16135-46. Epub 2008 Mar 26. PMID:18367445 doi:https://dx.doi.org/10.1074/jbc.M710323200
- ↑ Cason AL, Ikeguchi Y, Skinner C, Wood TC, Holden KR, Lubs HA, Martinez F, Simensen RJ, Stevenson RE, Pegg AE, Schwartz CE. X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome. Eur J Hum Genet. 2003 Dec;11(12):937-44. PMID:14508504 doi:10.1038/sj.ejhg.5201072
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Spermine synthase
- Arrowsmith, C H.
- Bochkarev, A.
- Edwards, A M.
- Loppnau, P.
- Min, J.
- Pegg, A E.
- Plotnikov, A N.
- SGC, Structural Genomics Consortium.
- Sundstrom, M.
- Weigelt, J.
- Wu, H.
- Zeng, H.
- Phosphoprotein
- Sgc
- Spermidine aminopropyltransferase
- Spmsy
- Structural genomic
- Structural genomics consortium
- Transferase
