3ink: Difference between revisions
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{{STRUCTURE_3ink| PDB=3ink | SCENE= }} | {{STRUCTURE_3ink| PDB=3ink | SCENE= }} | ||
===UNRAVELING THE STRUCTURE OF INTERLEUKIN-2: REPLY=== | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. | |||
==About this Structure== | ==About this Structure== | ||
| Line 13: | Line 15: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:001631562</ref><ref group="xtra">PMID:009015358</ref><ref group="xtra">PMID:009237811</ref><references group="xtra"/> | <ref group="xtra">PMID:001631562</ref><ref group="xtra">PMID:009015358</ref><ref group="xtra">PMID:009237811</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Brandhuber, B J.]] | [[Category: Brandhuber, B J.]] | ||
[[Category: Mckay, D B.]] | [[Category: Mckay, D B.]] | ||
[[Category: Cytokine]] | [[Category: Cytokine]] | ||
Revision as of 06:01, 25 March 2013
UNRAVELING THE STRUCTURE OF INTERLEUKIN-2: REPLY
Disease
[IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Function
[IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
About this Structure
3ink is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Bazan JF. Unraveling the structure of IL-2. Science. 1992 Jul 17;257(5068):410-3. PMID:1631562
- Wang Y, Li L, Liu J, Wang Z, Jiang C, Liu X. The analgesic domain of IL-2. Biochem Biophys Res Commun. 1997 Jan 23;230(3):542-5. PMID:9015358 doi:10.1006/bbrc.1996.5961
- Eckenberg R, Xu D, Moreau JL, Bossus M, Mazie JC, Tartar A, Liu XY, Alzari PM, Bertoglio J, Theze J. Analysis of human IL-2/IL-2 receptor beta chain interactions: monoclonal antibody H2-8 and new IL-2 mutants define the critical role of alpha helix-A of IL-2. Cytokine. 1997 Jul;9(7):488-98. PMID:9237811 doi:10.1006/cyto.1996.0192
