CD4: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='2nxy' size='350' side='right' caption='Structure of CD4 complex with antibody and HIV-1 gp120 (PDB entry 2nxy)' scene=''> '''CD4''' (or '''Cluster of Diff... |
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<StructureSection load='2nxy' size='350' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (grey), TRIS and hexane-diol (PDB entry [[2nxy]])' scene=''> | |||
<StructureSection load='2nxy' size='350' side='right' caption='Structure of CD4 complex with antibody | |||
'''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains, a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway. HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell. | '''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains, a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway. HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell. | ||
