3cfs: Difference between revisions
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{{STRUCTURE_3cfs| PDB=3cfs | SCENE= }} | {{STRUCTURE_3cfs| PDB=3cfs | SCENE= }} | ||
===Structural basis of the interaction of RbAp46/RbAp48 with histone H4=== | ===Structural basis of the interaction of RbAp46/RbAp48 with histone H4=== | ||
{{ABSTRACT_PUBMED_18571423}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RBBP7_HUMAN RBBP7_HUMAN]] Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018571423</ref><references group="xtra"/> | <ref group="xtra">PMID:018571423</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ben-Shahar, T R.]] | [[Category: Ben-Shahar, T R.]] | ||
Revision as of 11:25, 3 July 2013
Structural basis of the interaction of RbAp46/RbAp48 with histone H4
Template:ABSTRACT PUBMED 18571423
Function
[RBBP7_HUMAN] Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.[1]
About this Structure
3cfs is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Murzina NV, Pei XY, Zhang W, Sparkes M, Vicente-Garcia J, Pratap JV, McLaughlin SH, Ben-Shahar TR, Verreault A, Luisi BF, Laue ED. Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. Structure. 2008 Jul;16(7):1077-85. Epub 2008 Jun 19. PMID:18571423 doi:https://dx.doi.org/10.1016/j.str.2008.05.006
Proteopedia Page Contributors and Editors (what is this?)
- Homo sapiens
- Ben-Shahar, T R.
- Laue, E D.
- Luisi, B F.
- Murzina, N V.
- Pei, X-Y.
- Pratap, J V.
- Sparkes, M.
- Verreault, A.
- Vicente-Garcia, J.
- Chaperone
- Chromatin
- Chromatin regulator
- Chromosomal protein
- Dna replication
- Histone
- Histone-chaperone complex
- Nucleosome core
- Nucleus
- Phosphoprotein
- Rbap46/rbap48
- Repressor
- Transcription
- Transcription regulation
- Wd repeat
- Wd-40 repeat protein
