4g6m: Difference between revisions
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{{STRUCTURE_4g6m| PDB=4g6m | SCENE= }} | {{STRUCTURE_4g6m| PDB=4g6m | SCENE= }} | ||
===Crystal strucure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab=== | ===Crystal strucure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab=== | ||
{{ABSTRACT_PUBMED_23041424}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN]] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4g6m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6M OCA]. | [[4g6m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6M OCA]. | ||
==See Also== | |||
*[[Interleukin|Interleukin]] | |||
==Reference== | |||
<ref group="xtra">PMID:023041424</ref><references group="xtra"/><references/> | |||
[[Category: Blech, M.]] | [[Category: Blech, M.]] | ||
[[Category: Hoerer, S.]] | [[Category: Hoerer, S.]] | ||
Revision as of 04:31, 18 July 2013
Crystal strucure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab
Template:ABSTRACT PUBMED 23041424
Function
[IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.[1]
About this Structure
4g6m is a 3 chain structure. Full crystallographic information is available from OCA.
See Also
Reference
- Blech M, Peter D, Fischer P, Bauer MM, Hafner M, Zeeb M, Nar H. One Target-Two Different Binding Modes: Structural Insights into Gevokizumab and Canakinumab Interactions to Interleukin-1beta J Mol Biol. 2012 Oct 3. pii: S0022-2836(12)00786-3. doi:, 10.1016/j.jmb.2012.09.021. PMID:23041424 doi:10.1016/j.jmb.2012.09.021
