3rbg: Difference between revisions

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{{STRUCTURE_3rbg|  PDB=3rbg  |  SCENE=  }}  
{{STRUCTURE_3rbg|  PDB=3rbg  |  SCENE=  }}  
===Crystal structure analysis of Class-I MHC restricted T-cell associated molecule===
===Crystal structure analysis of Class-I MHC restricted T-cell associated molecule===
{{ABSTRACT_PUBMED_23583034}}
==Function==
[[http://www.uniprot.org/uniprot/CRTAM_HUMAN CRTAM_HUMAN]] Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.<ref>PMID:15811952</ref> [UniProtKB:Q149L7]


==About this Structure==
==About this Structure==
[[3rbg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBG OCA].  
[[3rbg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBG OCA].  
==Reference==
<ref group="xtra">PMID:023583034</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Almo, S C.]]
[[Category: Almo, S C.]]

Revision as of 19:23, 7 August 2013

Template:STRUCTURE 3rbg

Crystal structure analysis of Class-I MHC restricted T-cell associated molecule

Template:ABSTRACT PUBMED 23583034

Function

[CRTAM_HUMAN] Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.[1] [UniProtKB:Q149L7]

About this Structure

3rbg is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Rubinstein R, Ramagopal UA, Nathenson SG, Almo SC, Fiser A. Functional classification of immune regulatory proteins. Structure. 2013 May 7;21(5):766-76. doi: 10.1016/j.str.2013.02.022. Epub 2013 Apr, 11. PMID:23583034 doi:10.1016/j.str.2013.02.022
  1. ↑ Boles KS, Barchet W, Diacovo T, Cella M, Colonna M. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. Blood. 2005 Aug 1;106(3):779-86. Epub 2005 Apr 5. PMID:15811952 doi:10.1182/blood-2005-02-0817

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